Fireworks (a great unknown app)
When it comes to Macromedia applications, Dreamweaver and Flash are the well-knowns with ColdFusion gaining in popularity. Much less talked about is their great image-editing program Fireworks. It surprises me how many people do most of their web image editing in big programs like Photoshop. Photoshop is a great tool and the best tool for doing many things, but I think it's often not the most effective tool for creating quick and simple graphics. Switchboard has a short writeup on Fireworks making this point.